is a Distinguished Professor of Chemistry, Biochemistry, and Pharmacology specializing in lipid research at the University of California San Diego School of Medicine. Dr. Dennis was a long-time Editor-in-Chief for the Journal of Lipid Research and on the Editorial Board of the Journal of Cellular Biochemistry. Dr. Dennis has 375 peer-reviewed scientific publications and has received many awards, including the Avanti Award for Research in Lipid Biochemistry from the American Society of Biochemistry and Molecular Biology.
Did you know?
Dr. Dennis is a gradate of Yale University (BA) and Harvard University (MA, PhD, Postdoctoral) and has honorary Doctorate degrees from Goethe University of Frankfurt (Germany) and the University of Lyon (France).
Molecular basis of unique specificity and regulation of group VIA calcium-independent phospholipase A2 (PNPLA9) and its role in neurodegenerative diseases. Pharmacol Ther. 2023 05; 245:108395. Hayashi D, Dennis EA. PMID: 36990122; PMCID: PMC10174669.
Allosteric regulation by membranes and hydrophobic subsites in phospholipase A2 enzymes determine their substrate specificity. J Biol Chem. 2022 05; 298(5):101873. Dennis EA. PMID: 35358512; PMCID: PMC9079178.
Bioactive lipids and metabolic syndrome-a symposium report. Ann N Y Acad Sci. 2022 05; 1511(1):87-106. DeVito LM, Dennis EA, Kahn BB, Shulman GI, Witztum JL, Sadhu S, Nickels J, Spite M, Smyth S, Spiegel S. PMID: 35218041; PMCID: PMC9219555.
N-Acylated and N-Alkylated 2-Aminobenzothiazoles Are Novel Agents That Suppress the Generation of Prostaglandin E2. Biomolecules. 2022 02 07; 12(2). Theodoropoulou MA, Psarra A, Erhardt M, Nikolaou A, Gerogiannopoulou AD, Hadjipavlou-Litina D, Hayashi D, Dennis EA, Huwiler A, Kokotos G. PMID: 35204768; PMCID: PMC8961538.
Lipoprotein-associated phospholipase A2: A paradigm for allosteric regulation by membranes. Proc Natl Acad Sci U S A. 2022 01 11; 119(2). Mouchlis VD, Hayashi D, Vasquez AM, Cao J, McCammon JA, Dennis EA. PMID: 34996868; PMCID: PMC8764669.
Each phospholipase A2 type exhibits distinct selectivity toward sn-1 ester, alkyl ether, and vinyl ether phospholipids. Biochim Biophys Acta Mol Cell Biol Lipids. 2022 01; 1867(1):159067. Hayashi D, Mouchlis VD, Dennis EA. PMID: 34634490; PMCID: PMC9188868.
Omega-3 versus Omega-6 fatty acid availability is controlled by hydrophobic site geometries of phospholipase A2s. J Lipid Res. 2021; 62:100113. Hayashi D, Mouchlis VD, Dennis EA. PMID: 34474084; PMCID: PMC8551542.
Quality control requirements for the correct annotation of lipidomics data. Nat Commun. 2021 08 06; 12(1):4771. Köfeler HC, Eichmann TO, Ahrends R, Bowden JA, Danne-Rasche N, Dennis EA, Fedorova M, Griffiths WJ, Han X, Hartler J, Holcapek M, Jirásko R, Koelmel JP, Ejsing CS, Liebisch G, Ni Z, O'Donnell VB, Quehenberger O, Schwudke D, Shevchenko A, Wakelam MJO, Wenk MR, Wolrab D, Ekroos K. PMID: 34362906; PMCID: PMC8346590.
Steps Toward Minimal Reporting Standards for Lipidomics Mass Spectrometry in Biomedical Research Publications. Circ Genom Precis Med. 2020 12; 13(6):e003019. O'Donnell VB, FitzGerald GA, Murphy RC, Liebisch G, Dennis EA, Quehenberger O, Subramaniam S, Wakelam MJO. PMID: 33196315; PMCID: PMC8376269.
Update on LIPID MAPS classification, nomenclature, and shorthand notation for MS-derived lipid structures. J Lipid Res. 2020 12; 61(12):1539-1555. Liebisch G, Fahy E, Aoki J, Dennis EA, Durand T, Ejsing CS, Fedorova M, Feussner I, Griffiths WJ, Köfeler H, Merrill AH, Murphy RC, O'Donnell VB, Oskolkova O, Subramaniam S, Wakelam MJO, Spener F. PMID: 33037133; PMCID: PMC7707175.
Automated Annotation of Sphingolipids Including Accurate Identification of Hydroxylation Sites Using MSn Data. Anal Chem. 2020 10 20; 92(20):14054-14062. Hartler J, Armando AM, Trötzmüller M, Dennis EA, Köfeler HC, Quehenberger O. PMID: 33003696; PMCID: PMC7581017.
A global lipid map defines a network essential for Zika virus replication. Nat Commun. 2020 07 21; 11(1):3652. Leier HC, Weinstein JB, Kyle JE, Lee JY, Bramer LM, Stratton KG, Kempthorne D, Navratil AR, Tafesse EG, Hornemann T, Messer WB, Dennis EA, Metz TO, Barklis E, Tafesse FG. PMID: 32694525; PMCID: PMC7374707.
PPARα exacerbates necroptosis, leading to increased mortality in postinfluenza bacterial superinfection. Proc Natl Acad Sci U S A. 2020 07 07; 117(27):15789-15798. Tam VC, Suen R, Treuting PM, Armando A, Lucarelli R, Gorrochotegui-Escalante N, Diercks AH, Quehenberger O, Dennis EA, Aderem A, Gold ES. PMID: 32581129; PMCID: PMC7355019.
Plasma eicosanoids as noninvasive biomarkers of liver fibrosis in patients with nonalcoholic steatohepatitis. Therap Adv Gastroenterol. 2020; 13:1756284820923904. Caussy C, Chuang JC, Billin A, Hu T, Wang Y, Subramanian GM, Djedjos CS, Myers RP, Dennis EA, Loomba R. PMID: 32523627; PMCID: PMC7257854.
Efficacy of dietary odd-chain saturated fatty acid pentadecanoic acid parallels broad associated health benefits in humans: could it be essential? Sci Rep. 2020 05 18; 10(1):8161. Venn-Watson S, Lumpkin R, Dennis EA. PMID: 32424181; PMCID: PMC7235264.
2-Oxoester Phospholipase A2 Inhibitors with Enhanced Metabolic Stability. Biomolecules. 2020 03 24; 10(3). Koutoulogenis GS, Kokotou MG, Hayashi D, Mouchlis VD, Dennis EA, Kokotos G. PMID: 32213911; PMCID: PMC7175278.
Lipidomics-based assays coupled with computational approaches can identify novel phospholipase A2 inhibitors. Adv Biol Regul. 2020 05; 76:100719. Mouchlis VD, Mu C, Hammons R, Dennis EA. PMID: 32199750; PMCID: PMC7230010.
IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol. 2020 05; 72(5):946-959. Ma HY, Yamamoto G, Xu J, Liu X, Karin D, Kim JY, Alexandrov LB, Koyama Y, Nishio T, Benner C, Heinz S, Rosenthal SB, Liang S, Sun M, Karin G, Zhao P, Brodt P, Mckillop IH, Quehenberger O, Dennis E, Saltiel A, Tsukamoto H, Gao B, Karin M, Brenner DA, Kisseleva T. PMID: 31899206; PMCID: PMC7167339.
Correction to "Highly Potent 2-Oxoester Inhibitors of Cytosolic Phospholipase A2 (GIVA cPLA2)". ACS Omega. 2019 Jun 30; 4(6):10714. Psarra A, Kokotou MG, Galiatsatou G, Mouchlis VD, Dennis EA, Kokotos G. PMID: 31460169; PMCID: PMC6648946.
AMP-activated protein kinase activation ameliorates eicosanoid dysregulation in high-fat-induced kidney disease in mice. J Lipid Res. 2019 05; 60(5):937-952. Declèves AE, Mathew AV, Armando AM, Han X, Dennis EA, Quehenberger O, Sharma K. PMID: 30862696; PMCID: PMC6495162.
β-Lactones: A Novel Class of Ca2+-Independent Phospholipase A2 (Group VIA iPLA2) Inhibitors with the Ability To Inhibit β-Cell Apoptosis. J Med Chem. 2019 03 28; 62(6):2916-2927. Dedaki C, Kokotou MG, Mouchlis VD, Limnios D, Lei X, Mu CT, Ramanadham S, Magrioti V, Dennis EA, Kokotos G. PMID: 30798607; PMCID: PMC6767909.
Substrate-Specific Inhibition Constants for Phospholipase A2 Acting on Unique Phospholipid Substrates in Mixed Micelles and Membranes Using Lipidomics. J Med Chem. 2019 02 28; 62(4):1999-2007. Mouchlis VD, Armando A, Dennis EA. PMID: 30615445; PMCID: PMC6398150.
Directed Non-targeted Mass Spectrometry and Chemical Networking for Discovery of Eicosanoids and Related Oxylipins. Cell Chem Biol. 2019 03 21; 26(3):433-442.e4. Watrous JD, Niiranen TJ, Lagerborg KA, Henglin M, Xu YJ, Rong J, Sharma S, Vasan RS, Larson MG, Armando A, Mora S, Quehenberger O, Dennis EA, Cheng S, Jain M. PMID: 30661990; PMCID: PMC6636917.
LIPID MAPS: Serving the next generation of lipid researchers with tools, resources, data, and training. Sci Signal. 2019 01 08; 12(563). O'Donnell VB, Dennis EA, Wakelam MJO, Subramaniam S. PMID: 30622195.
Inhibition of spinal 15-LOX-1 attenuates TLR4-dependent, nonsteroidal anti-inflammatory drug-unresponsive hyperalgesia in male rats. Pain. 2018 Dec; 159(12):2620-2629. Gregus AM, Buczynski MW, Dumlao DS, Norris PC, Rai G, Simeonov A, Maloney DJ, Jadhav A, Xu Q, Wei SC, Fitzsimmons BL, Dennis EA, Yaksh TL. PMID: 30130298; PMCID: PMC6237621.
Quantitative determination of esterified eicosanoids and related oxygenated metabolites after base hydrolysis. J Lipid Res. 2018 12; 59(12):2436-2445. Quehenberger O, Dahlberg-Wright S, Jiang J, Armando AM, Dennis EA. PMID: 30323111; PMCID: PMC6277157.
Meet the rest of our team
The team behind the vision.
Society spent a generation avoiding fat, we’ve dedicated our lives to harnessing it.
Stephanie Venn-Watson, DVM, MPH
Steph is a serial entrepreneur of for-profit and not-for-profit companies, a veterinary epidemiologist and public health scientist with over 40 patents and 70 peer-reviewed scientific publications, and previously served as an epidemiologist tracking diseases for the Centers for Disease Control and Prevention and World Health Organization.
Eric Venn-Watson, MD, MBA
Eric is a practicing physician and entrepreneur. He served over 25 years as a Navy and Marine Corps physician, working with the special forces community to improve their health and fitness. Additionally, Eric founded multiple companies in the drug discovery, healthcare analytics, and medical device industries. He is passionate about developing medical technologies that improve the practice and delivery of healthcare on a global scale.
Kim Kamdar, PhD
Board Chair, Co-Founder
Kim is a Managing Partner of Domain Associates, a life sciences venture capital firm, and has been involved in numerous cutting-edge therapeutic start-ups. She was also a research director at Novartis, where she led a team to uncover small molecules that modulated signaling pathway networks.
Nicholas Schork, PhD
Senior Scientist, Co-Founder
Nicholas is a Distinguished Professor and Director of the Quantitative Medicine and Systems Biology Division at Translational Genomics Institute, an affiliate of The City of Hope. In addition, as a leader in the design and analysis of studies of longevity, Nicholas is Scientific Director for the National Institute of Health’s National Institute of Aging-sponsored Longevity Consortium.
Chief Financial Officer
Chris is a finance leader focused on driving scale and profitability for high-growth businesses. Throughout his career, Chris has worked with both small and large companies to develop growth strategies, navigate operational hurdles, execute M&A transactions, and raise capital. He is passionate about developing data-driven insights to support long-term, sustainable business expansion. Chris began his career in investment banking at J.P. Morgan and Moelis, and he has held finance roles at Mars Wrigley, KIND and Diggs.
Dennis Bernstein, MBA
VP of Marketing & Growth
Dennis is a marketing and brand builder, with an entrepreneurial mindset. He has 20+ years of experience leading the development of innovative brands and launching successful consumer products into the marketplace, working at some of the most rapidly evolving Omni-channel and DTC companies, including Procter & Gamble and Dollar Shave Club. Dennis developed and led such projects as the Thank you Mom campaign for the London Olympics and global launches for the Crest/Oral B and Gillette brands.
Head of Consumer Experience & Engagement
Ali is an expert when it comes to marketing and community building, with the number one priority of always putting the customer first. Ali's mission is to make customers’ feel like friends and part of the fatty15 family, helping people with any requests. With over 23+ years of marketing experience on both the agency and client side of the business building communities, at companies like Empower MediaMarketing, Ali enjoys bringing her personable nature to the fatty15 family.
Kate is a highly motivated professional experienced in non-profit fundraising, event and project management. With her leadership, organizational skills, effective communication, and optimistic attitude, she is an invaluable asset as our project manager. She excels in maintaining a holistic perspective while also paying meticulous attention to detail. Kate proactively seeks opportunities to improve and enhance processes for the benefit of the entire team.
Living abroad as a military family has honed her change management abilities and broadened her global perspective, fueling her desire to work for companies that make a positive impact on people's lives. She finds immense satisfaction in her role at Seraphina Therapeutics, where she actively contributes to their mission of advancing global health through the transformative fatty acid C15:0.
Head of Content and Community
Ken is a marketing professional and content creator who loves a good time. With over 10 years of experience working for direct-to-consumer brands and major fashion retailers like Bloomingdale’s and Victoria’s Secret, his mission is to develop larger-than-life experiences
across social media and other interactive platforms that allow everyone to be part of the story.
Edward Dennis, PhD
Ed is a Distinguished Professor of Chemistry, Biochemistry and Pharmacology specializing in lipid research at the University of California San Diego School of Medicine. Ed, who is a graduate of Yale University and Harvard University, was Editor-in-Chief of the Journal of Lipid Research and has 375 peer-reviewed publications, including roles of fatty acids in health.
Ronald Krauss, MD
Ron is a Senior Scientist and Director of Atherosclerosis Research at Children's Hospital Oakland Research Institute and Adjunct Professor in the Department of Medicine at UCSF and the Department of Nutritional Sciences at UC Berkeley. Ron is a graduate of Harvard University, is board-certified in internal medicine, endocrinology and metabolism, and is a Fellow of the American Society of Nutrition and American Heart Association. He has 450 peer-reviewed publications, including leading papers on dairy-based fats and health.
Daniel Einhorn, MD
Medical Advisor, Endocrinology
Dr. Einhorn is the president of the American Association of Clinical Endocrinologists, medical director of the Scripps Whittier Diabetes Institute and Clinical Professor of Medicine at UCSD. He is an editor and contributor to numerous books and articles, including publications from the American Medical Association and the Royal Society of Medicine, and has been a teacher in graduate medical education throughout the world.