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Fatty15 Near-Term Benefits and Long-Term Gains

Published by Dr. Venn-Watson
    • Essential micronutrients are critical nutrients our bodies must have in order to stay healthy. Examples include vitamins and essential fatty acids.
    • C15:0 is a trace saturated fat in butter and some types of fish and plants that science now supports is an essential fatty acid. Fatty15 (containing FA15TM, a pure powder form of C15:0) supports our long-term metabolic, immune, red blood cell, and liver health.*
    • By naturally binding to receptors called PPARs throughout our body, fatty15 can also help with near-term benefits, including improved sleep, feeling calmer, having more balanced energy and mood throughout the day, and decreased snacking between meals.*

Most of us will take one type of supplement to support our general health (think, vitamins), and other types of supplements to address more specific needs, like one for cholesterol support and another for improved sleep.

When a dietary supplement is truly essential, however, it has the potential to help protect both our long-term general health and more specific, near-term health that we can feel.

Sound good? Well, read on.

C15:0 (aka the pure ingredient in fatty15) is an odd-chain saturated fatty acid present in trace levels in butter, other whole fat dairy products, and some types of fish and plants. A growing body of science supports that C15:0 is an essential micronutrient that we need to sustain health. Which means that without adequate C15:0 levels, we may not be able to maintain an optimal healthy state.*

What evidence supports that C15:0 is essential for my general health?

In order to be considered 'essential', a nutrient needs to meet the following three criteria:

  • Low body levels of the nutrient results in poorer health
  • The body doesn't make enough of the nutrient on its own
  • The primary source of the nutrient is through diet or supplements

Until now, only two fatty acids have met these criteria: alpha-linolenic acid (an omega-3 fatty acid) and linoleic acid (an omega-6 fatty acid). So, let’s look at where C15:0 lands with each of the criteria for 'essentiality'.

First, low C15:0 body levels are associated with poorer health.*  Large population studies throughout the world have repeatedly shown significant associations between low C15:0 in our diet and/or body and poorer metabolic, immune, and liver health. A large-scale study involving over 14,000 individuals showed that people who had less C15:0 in their diets had a higher risk of mortality over a 14-year period.

While these studies all showed associations between low C15:0 and poorer health, we published a series of studies that demonstrated C15:0 as the cause of good metabolic, immune, red blood cell, and liver health. So, checkmark - growing evidence supports that we need adequate levels of C15:0 in our bodies to stay healthy.

Second, our body doesn’t make enough C15:0 on its own. While there is evidence that other odd-chain saturated fatty acids (like C17:0) can be made by our bodies, studies repeatedly show that our circulating C15:0 levels reflect how much C15:0 we eat. Yep, that means we can become deficient in C15:0 if we don’t eat enough of it – and that we can restore our levels only by eating more foods (or fatty15) with C15:0 in it.* In fact, our published studies have shown that C15:0 supplementation with fatty15 increases both C15:0 and C17:0 blood levels, giving you a double benefit of increasing two types of beneficial odd-chain saturated fatty acids.

Finally, our primary source of C15:0 is through the diet – specifically, whole fat dairy products. C15:0 blood levels have long been used as a way to measure how much whole fat dairy one eats, meaning whole fat dairy is our most important dietary source of C15:0. The problem is, we have been told for decades not to eat whole fat dairy products, and as a result, population-wide C15:0 blood levels have been declining.

To protect your general health, fatty15 enables you to restore and maintain your C15:0 levels in a pure and vegan-friendly way.* That means you don't have to go back to eating a bunch of whole fat dairy products (which contain much higher levels of the bad even-chain saturated fats) in order to get your proper amount of daily C15:0.

Okay, I get that evidence supports C15:0 as essential for my metabolic, immune, red blood cell, and liver long-term health.* Are there any benefits of taking fatty15 that I may feel in the near-term?

Yes, about 6 in 10 fatty15 customers report at least one of the following benefits within their first six week on daily fatty15:*

These nearer-term health benefits are most likely due to fatty15’s role as a natural activator of two key receptors, called PPARs (pronounced pee-pars) alpha and delta, that are present throughout our body - including our brain. PPARs are well-known regulators of metabolism and immunity, which helps to explain how fatty15 naturally protects our long-term metabolic and immune health.

In addition to these long-term benefits, however, there are an increasing number of studies support the role of PPARs in regulating our mood, stress, sleep patterns, energy, and hunger. Here are just a few things PPAR activators (especially PPAR alpha activators) can do:

  • Improve mood and provide neuroprotective effects by activating PPAR alpha receptors in the amygdala and hippocampus, resulting in lowered stress and anxiety.
  • Help to regulate sleep and circadian rhythms by binding to PPAR alpha receptors in the brain, which can improve the quality and depth of sleep.
  • Lessen hunger by activating PPAR alpha receptors that impact vagal activity and decrease the desire to eat between meals.

As a natural PPAR alpha activator, fatty15 has the ability to help you both long-term (i.e. metabolic, immune, and liver health), and in some cases, even near-term (i.e. improved mood, sleep, and eating habits).*

Similar to other essential fatty acids and depending on individuals’ differences in age, gender, and lifestyle, some people may be more likely to experience these near-term benefits than others. Whether or not you feel the near-term effects of fatty15, rest assured that it is busy working on its long-term benefits to your general health, too.*

Read the science 

For a summary of peer-reviewed and published science on C15:0 (pentadecanoic acid), including our studies in Scientific Reports supporting C15:0 as an essential fatty acid and natural PPAR activator, please click here.




Profile photo for Eric Venn-Watson

Eric Venn-Watson M.D.

Eric is a physician, U.S. Navy veteran, and Co-founder and COO of Seraphina Therapeutics. Eric served over 25 years as a Navy and Marine Corps physician, working with the special forces community to improve their health and fitness. Seraphina Therapeutics is a health and wellness company dedicated to advancing global health through the discovery of essential fatty acids and micronutrient therapeutics.

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