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2025 Longevity Review: Anti‑Aging Benefits of Fatty15’s C15:0

Published by Dr. Venn-Watson
Dr. Eric Venn-Watson’s Highlights

Introduction to Fatty15 and C15:0

Fatty15 represents a breakthrough in the field of longevity supplements, built around the discovery of C15:0 (pentadecanoic acid), an odd-chain saturated fatty acid newly recognized as essential for human health. Identified by researchers dedicated to improving the long-term health of Navy dolphins, C15:0 has emerged as a critical nutrient for supporting cellular health, regulating immunity, and promoting metabolic balance.

With over 100 peer-reviewed studies supporting C15:0’s long-term health benefits, it is being called ‘The Longevity Nutrient’. Fatty15 is a bioavailable, patented, and award-winning supplement that delivers pure C15:0. Fatty15 stands out for its science-backed approach and sustainable ethos. 

Scientific Discovery Behind C15:0 

The significance of C15:0 in the realm of longevity was first uncovered while helping to continually improve the health of older Navy dolphins. Doctors observed that dolphins with higher levels of C15:0 had better long-term health, which was also observed in humans. 

Since those early observations, scientists over the past decade have discovered that C15:0 is an emerging essential fatty acid that actively supports healthy aging and long-term health in all animals, including dolphins and humans. Today, peer-reviewed studies have shown how C15:0 is a geroprotector, or a molecule that can slow aging rates and improve long-term health. It does this in part by targeting the human longevity-regulating pathway and multiple hallmarks of aging, including poor cellular signaling, inflammaging, and mitochondrial dysfunction.

Key Milestones in C15:0 Longevity Research:

  • Dolphin studies uncover link between C15:0 and healthspan.

  • Human translational research confirms C15:0’s essential role in cellular health.

  • Peer-reviewed evidence establishes C15:0 as an essential nutrient and geroprotector, setting it apart from omega-3, the only other essential fatty acid.

  • Fatty15 launches as the first supplement delivering a science-backed, patented, sustainably produced, vegan, and pure C15:0 ingredient.

The discovery of C15:0 and the ability of this essential nutrient to strengthen cells and target longevity-enhancing pathways is helping to define what a healthy aging and longevity nutrient is. 

Key Anti-Aging Benefits of C15:0

C15:0 works across multiple cellular systems to help slow and even reverse cellular aging. More than 100 peer-reviewed publications from academic institutions around the world support C15:0’s benefits to cellular, metabolic, cardiovascular, immune, and long-term health. 

Benefit

Mechanism

Supporting Study/Evidence

Cellular protection

Strengthens membranes, repairs mitochondria

Fatty15 science deep dive

Metabolic health

Activates AMPK/PPAR, improves lipid/glucose profiles

Jill Carnahan, 2025

Anti-inflammatory effects

Reduces chronic inflammation and fibrosis

PMC10649853

Immune support, well-being

Regulates immune function, improves sleep/mood

Innerbody review

Slows biological aging

Improves aging-related biomarkers, reduces epigenetic aging

Fatty15 science deep dive

Cellular Protection and Membrane Stability

Maintenance of strong cell membranes and healthy mitochondria is fundamental to slowing aging at the cellular level. C15:0 has been shown to reinforce the integrity of cell membranes, reduce lipid peroxidation (a process that damages cells), and repair mitochondrial function. 

This cellular fortification not only boosts energy production but also promotes longevity by clearing out damaged, senescent “zombie” cells via AMPK activation and mTOR inhibition, which is vital for maintaining youthful cellular populations.

Metabolic Health and Longevity Pathways

C15:0’s activation of AMPK and PPAR signaling pathways is important to its longevity benefits. These pathways regulate cellular energy, inflammation, and metabolic homeostasis. 

Higher levels of C15:0 are associated with improved cholesterol and lipid profiles, and a “younger” biological age. Just 100 mg of C15:0 daily has been shown to maintain levels that support metabolic, liver, and red blood cell health, making fatty15 an effective anti-aging supplement.

Supports a Healthy Inflammatory Response

Chronic, low-grade inflammation is linked to accelerated aging and age-related health concerns. Emerging research suggests that C15:0 may support the body’s natural inflammatory balance, with higher blood levels associated with healthy systemic inflammation markers. 

These findings position C15:0 as a promising nutrient for supporting overall healthy aging, with effects observed in research settings similar to those seen with well-studied compounds such as metformin and rapamycin.

Immune Support and Overall Well-Being

Fatty15’s C15:0 has also been shown to support immune function. Based on a survey with 6,243 fatty15 customers, 70% report seeing or feeling benefits within 16 weeks, including better sleep, improved energy, healthier mood, or overall improved health* 

Outcome

Seen in Research

Reported by Users

Improved sleep quality

Yes

Yes

Enhanced mood and focus

Yes

Yes

Increased energy

Yes

Yes

Healthier immune markers

Yes

Impact on Biological Aging and Longevity Markers

Chronological age reflects years lived, while biological age measures the health and function of your cells. C15:0 supplementation has been linked to a “younger” biological age by multiple biological clocks that measure, among other things, epigenetic changes and lab biomarkers.

More specifically, C15:0 slows hallmark epigenetic alterations—changes in gene expression patterns that drive cellular aging. These measurable shifts help explain the potential benefits of fatty15 to our long-term health and wellness.

Recommended Usage and Dosage of Fatty15

The recommended daily dose of fatty15 is 100–200 mg of pure C15:0. This dosing is supported by published peer-reviewed research for healthy blood lipid levels, metabolic function, and cellular resilience. 

Many users also notice near-term improvements, such as better mood and sleep, as well as increased energy throughout the day, within a few weeks. Objective changes in markers like cholesterol, liver function, and red blood cell indices are often noted within 16 weeks of consistent use.

Safety Profile and Clinical Validation

Fatty15 has been studied extensively for safety and has achieved regulatory GRAS status. Additionally, it has one of the highest Suppco Trust scores at 9.63. Fatty15 has undergone rigorous testing in the peer-reviewed literature, including multiple randomized controlled trials supporting its benefits for liver, metabolic, and red blood cell health. 

While the body of evidence is robust, additional independent studies are continuing to be published on a regular basis. According to leading longevity scientists, fatty15 is quickly becoming a leading healthy aging and longevity supplement. 

How C15:0 Differs From Other Longevity Ingredients

C15:0 stands apart from other anti-aging supplements such as omega-3s, resveratrol, or NAD+ precursors, thanks to its unique cellular mechanisms and impacts on the hallmarks of aging. 

Ingredient

Aging Hallmarks Addressed

Mechanism

Research Evidence

C15:0

6+

Cellular membrane strength, AMPK/PPAR

Growing body of evidence, including 100+ studies, RCTs

Omega-3

2–3

Anti-inflammatory

Large body of evidence with mixed support

Resveratrol

1–2

SIRT1 activation

Moderate body of evidence with mixed clinical support

NAD+ prec.

1–2

Cellular energy (NAD+ boost)

Moderate body of evidence with mixed clinical support

Summary of Research Findings and Consumer Impact

Fatty15’s pure C15:0 supplement is helping to define what a healthy aging and longevity supplement is, with a growing body of evidence supporting its role in strengthening our cells and improving our metabolic, liver, immune, and red blood cell health. Over 100,000 people are taking fatty15, and many have reported improved sleep, mood, and energy, in addition to improvements in their blood labs.

With a science-backed foundation and a growing community, fatty15 is shaping the future of healthy aging and longevity supplementation. Readers are encouraged to review the research, monitor their wellness markers, and engage with the fatty15 community for ongoing support and results.

Frequently Asked Questions

What Is C15:0 and Why Is It Important for Aging?

C15:0 (pentadecanoic acid) is a newly discovered essential fatty acid that supports cellular health, strengthens cell membranes, and restores mitochondrial function to help slow or reverse cellular aging.

How Does Fatty15 Support Cellular Health and Metabolism?

Fatty15’s pure C15:0 ingredient strengthens cell membranes, repairs mitochondria, and activates longevity pathways, leading to supported metabolic, liver, immune, and red blood cell health.

What Is the Recommended Daily Dosage and How Soon Are Benefits Seen?

The daily dosage of Fatty15 is 100 to 200 mg, with subjective benefits like improved mood and sleep often noticed within a few weeks, and measurable lab improvements usually seen in about 16 weeks.

Who Should Consult a Healthcare Provider Before Taking Fatty15?

Fatty15 has been shown to be safe in multiple clinical trials and has achieved GRAS (generally recognized as safe) status. As with any supplement, it is always recommended to consult with a healthcare provider before starting a new supplement regimen. 

How Can Consumers Track Their Progress Using C15:0?

Consumers can monitor their progress with fatty15 by monitoring for near-term benefits, by checking their C15:0 levels, and by monitoring lab markers of metabolic, liver, immune, and red blood cell health.

Profile photo for Eric Venn-Watson

Eric Venn-Watson M.D.

Eric is a physician, U.S. Navy veteran, and Co-founder and COO of Seraphina Therapeutics. Eric served over 25 years as a Navy and Marine Corps physician, working with the special forces community to improve their health and fitness. Seraphina Therapeutics is a health and wellness company dedicated to advancing global health through the discovery of essential fatty acids and micronutrient therapeutics.

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